This study demonstrated that ROS generate an overexpression of DUOX1 and DUOX2 in patients with CRSwNP, and the authors postulated that DUOX1 and DUOX2 are key factors in innate defense signal transduction and nasal mucosal inflammation in the human nasal airway epithelium. This evidence concerns the gene DUOX1 and chronic rhinosinusitis with nasal polyps.