Herein, we observed that the co-expression of IFN-γ-Granzyme-B and TNF-α-Perforin C were higher in SLE CD8+ T cells (Figure 1I–L), as was the dual expression of transcription factors T-bet and Eomes (Figure 1G,H). The gene discussed is GZMB; the disease is systemic lupus erythematosus.