Zn was also observed to alleviate cognitive impairment in rats when co-administered with Se, as these substances seem to stabilize the mitochondrial membranes and protect them from oxidative stress by increasing the SOD and GPx levels; in addition, Zn, together with Se and fish oil (eicosapentaenoic acid and docosahexaenoic acid), inhibits APP cleavage [561,562]. This evidence concerns the gene SOD1 and Cognitive impairment.