NFE2L2 and neurodegenerative disease: Besides neurons, the protective effect exerted by GSH on the brain endothelial cells is also of interest for neurodegenerative diseases, since it counteracts H2O2-mediated NO, ROS, and 8-hydroxy-2′-deoxyguanosine production, strengthens the tight junction proteins, and promotes the activity of the antioxidant Nrf2 pathway [452].