SOD enzyme activity was found significantly decreased in overweight and hypertensive subjects, 0.2 U/mL (0.1–0.6 U/mL), p < 0.01, contrary to that obtained in overweight subjects without hypertension, where the enzyme activity was increased, 0.8 U/mL (0.4–1.1 U/mL). Here, SOD1 is linked to Hypertension.