On the contrary, in Nrf2-KO mice, we found that ExT altered the status of 34 pathways (30 inhibitions and 4 activations), such as Nrf2-mediated oxidative stress responses, xenobiotic metabolism PXR signaling pathway, xenobiotic metabolism AHR signaling pathway, necroptosis signaling pathway, dilated cardiomyopathy signaling pathway, glutathione-mediated detoxification, and others. The gene discussed is NFE2L2; the disease is dilated cardiomyopathy.