In mice with artificial diabetes, the flavonoid morin increased NO levels and endothelial-dependent relaxation responses via Akt signaling, upregulating hosphor-Akt (at Ser473 and Thr308) and consequently hosphor-eNOS (at Ser1177) in aortas [101], as was also seen for protocatechuic acid in the aorta of male hypertensive rats [102]. Here, AKT1 is linked to diabetes mellitus.