NFE2L2 and chronic obstructive pulmonary disease: In addition, previous studies using animal models and in vitro have indicated that several chemical compounds have effects against oxidants related to COPD, including: AEOL 10150 (a superoxide dismutase mimetics) [127], Ebselen (a glutathione peroxidase mimetic) [128], Apocynin (a NADPH oxidase inhibitor) [90], AZD 5904 (a myeloperoxidate inhibitor) [44], L-NIL (an: inducible nitric oxide synthase inhibitor) [129], Bardoxolone methyl (a Nrf2 activator) [115], mitoQ, mitoTEMPO (mitochondria-targeted antioxidants) [130,131,132] (Figure 6).