Other studies have shown that the expression of genes encoding for markers of fat browning, such as uncoupling protein 1 (UCP1), PR domain-containing 16 (PRDM16), cell death-inducing DFFA-like effector protein A (CIDEA), cytochrome c oxidase subunit VIIa polypeptide 1 (COX7A1), peroxisome proliferator-activated receptor gamma coactivator 1α, transmembrane protein 26 (TMEM26), and T-box 1 (TBX1), were upregulated in adipose tissue adjacent to breast tumors. This evidence concerns the gene PRDM16 and breast neoplasm.