Other investigators demonstrated that cancer cells cultured with in vitro differentiated adipocytes or proinflammatory cytokines (IL-6, IL-8, CXCL10, CCL2 or CCL5) activate Src to upregulate Sox2 and induce miR-302b, generating feed-forward loops that contribute to mammary cancer stem cell self-renewal and drive metastatic tumor progression [61]. This evidence concerns the gene IL6 and breast cancer.