The transition of macrophages to the M2 phenotype facilitates tumor development, specifically through the production of anti-inflammatory cytokines (IL-10, arginase-1, TGF-β), as well as proangiogenic factors (CCL2, placental growth factor (PGF) and VEGF-A), which together favor tumor growth and metastasis [92,143,144]. Here, ARG1 is linked to neoplasm.