In an adipose triglyceride lipase/hormone-sensitive lipase (ATGL/HSL-dependent manner, adipocytes release fatty acids to boost fatty acid metabolism in breast cancer cells through the increased expression of carnitine palmitoyl transferase I (CPT1A) together with proteins of the electron transport chain, resulting in increased proliferation, migration and invasion of breast cancer cells [65,66]. The gene discussed is LIPE; the disease is breast cancer.