CCL2 and neoplasm: For instance, HFD-induced obese mice showed increases in VEGF, IL-6, chemokine ligand 2 (CCL2), and C-X-C motif chemokine ligand 1/2/13 (CXCL1/2/13), which promote angiogenesis and the infiltration of immune cells that favor tumor development and metastasis [49].