Furthermore, in STZ-treated diabetic mice and db/db mice, proximal tubule-specific overexpression of CAT in DN reduced angiotensinogen, p53, and proapoptotic Bcl-2 associated X-protein (BAX) gene expression and decreased renal ROS generation and tubulointerstitial fibrosis [132,133]. The gene discussed is CAT; the disease is liver dysplastic nodule.