However, male Nrf2 KO mice had a 2-fold increase (p < 0.05) in average tumor burden (4.05 ± 0.6 mm3 in males compared to 1.9 ± 0.3 mm3 in females) and an overall trend toward increased severity in tumor histopathology compared to female Nrf2 KO mice (Table S3). This evidence concerns the gene NFE2L2 and neoplasm.