The Nrf2-dependent increase in expression of the M1 macrophage markers TNFα, IL-6, and MHC-II and the decrease in the M2 macrophage markers VEGF, CCL2, and CD206 at the transcriptional, protein, and surface marker level in macrophages stimulated with conditioned media from lung cancer cells suggest that CDDO-Me redirects the polarization of lung tumor-educated macrophages to an anti-tumor phenotype through the activation of Nrf2. Here, NFE2L2 is linked to lung cancer.