The effect of juglone on cancer cells occurred via different mechanisms, including the induction of apoptosis, autophagy, inhibition of cell proliferation, invasion and migration of cells, in addition to its influence on different cell signaling pathways, such as interleukin 6 (IL-6)/STAT3, AMP-activated protein kinase (AMPK), mitogen- activated protein kinases (MAPK), glycogen synthase kinase-3 (GSK3) protein kinases, and the PI3K/AKT/mTOR [6,7,8,9,10,11]. The gene discussed is IL6; the disease is cancer.