Furthermore, the overexpression of some HSA21 genes, e.g., APP and DYRK1A, and the dysregulation of gene/protein expression associated with the trisomy contribute to the increase of oxidative stress in DS [82,83,84], suggesting that reduced APP amyloidogenic cleavage and DYRK1A protein levels might account for the observed decrease of oxidative stress levels in Ts-P frontal cortex. This evidence concerns the gene APP and Dravet syndrome.