We wanted to evaluate the impact of Alox5 and Elovl4 genes over the functional landscape of the disease; therefore, we disaggregated the individual contribution of each target and each circuit to the prediction model, obtaining the impact of ALOX5 and ELOVL4 over all the circuits involved in RP, according to ORPHANET and KEGG. This evidence concerns the gene ALOX5 and retinitis pigmentosa 1.