PPARA and liver disorder: In the liver tissue, recent studies have verified the beneficial roles of Sirt1 in various liver diseases including alcoholic liver diseases, non-alcoholic liver diseases, and cholestatic liver injury using animal models with the regulation of lipid metabolism (PPAR-α), antioxidant components (such as HO-1), and cell-death-related proteins or genes (p53 or Foxo1a) [41,42,43,44].