In rats with Alzheimer’s disease, ellagic acid from pomegranate peel not only decreases lipid peroxidation but also increases acetylcholinesterase activity and antioxidant enzymes (CAT, GSH, and Nrf2 nuclear/cytoplasmic ratio) and protects hippocampal CA1 pyramidal neurons in a rat model of Alzheimer’s disease. The gene discussed is ACHE; the disease is Alzheimer disease.