PPIG and chronic cystitis: In contrast, GSK2795039 treatment was highly effective in attenuating CYP-induced cystitis, as demonstrated by the significant reductions in the submucosal and muscularis edema (Figure 3A) in CYP + GSK2795039 in relation to CYP (Figure 3A), even though the bladder weight ratio was still higher than the controls (p < 0.05, Figure 3C).