JAK2 and cyclic hematopoiesis: As shown in Figure 6, except for adenosine, the other four ingredients I3XG, gluconic acid, uridine and guanosine have favorable docking affinity energy with JAK2 (−9.35, −4.63, −7.30 and −5.56 kcal mol−1), which further suggests the target role of JAK2 for the therapeutic effects of LBPE against CH.