TLR4 and ovarian carcinoma: Additionally, melatonin has been shown to be able to suppress the increased expression levels of proteins involved in ovarian cancer signalling, including epidermal growth factor receptor 2 (Her-2), p38 mitogen-activated protein kinase (p38 MAPK), protein kinase B (AKT), mammalian target of rapamycin (mTOR) [164], and toll-like receptor 4 (TLR4) [165].