On the other hand, melatonin may enhance the therapeutic effect of cisplatin in ovarian cancer as it has been proven that, in cisplatin-treated SK-OV-3 cells, the indolamine further promoted cytotoxicity and apoptosis through caspase-3 activation and through suppression of the extracellular signal-regulated kinase (ERK)/90-kDa ribosomal S6 kinase (p90RSK)/heat shock protein 27 (HSP27) cascade, thereby improving cisplatin-induced apoptosis [160]. This evidence concerns the gene CASP3 and ovarian carcinoma.