The malignant phenotype of murine melanoma B16-BL6 cells can be reversed by decreasing the level of ROS using antioxidant enzymes such as SOD [71]; ROS can interact with protein, kinases, and transcription factors through different pathways, leading to the regulation of several processes (proliferation, differentiation, apoptosis) depending on the nature and duration of the stimuli [8]. The gene discussed is SOD1; the disease is melanoma.