NOS2 and glioma: As shown in Figure 10, LPS-induced ROS overproduction and the expression of COX-2, iNOS, extracellular NO, and proinflammatory cytokines were mostly ameliorated in C6 glioma cells pretreated with the MyD88 inhibitor (NBP2–29328), indicating that MyD88 plays a central role in the transmission of LPS-mediated inflammatory signals on C6 glioma cells.