As shown in Figure 7B, the expression of TLR-4 and MyD88 was increased when LPS was treated with C6 glioma cells, but it was significantly (p < 0.05) diminished in C6 glioma cells treated with non-toxicological levels of IOE (0.1 and 0.2 mg/mL). Here, TLR4 is linked to central nervous system cancer.