Inhibition of the PI3K pathway by LY294002 or wortmannin blocked the cellular effects of NOX4 overexpression in NSCLC cells both in vitro and in vivo, implying a positive feedback loop between NOX4 and PI3K/Akt signaling contributes to NSCLC progression [52]. The gene discussed is PIK3CD; the disease is non-small cell lung carcinoma.