However, Abdel Fattah et al. [30] and Aminzadeh et al. [31] suggested that the MSCs’ hypoglycemic ability and their notable antioxidant activity in suppressing OS status is because of the persistent hyperglycemia, shown by the increased TAC, HO-1, GSH-Px-1, 3 and 4, SOD-1 and 3, CAT, and GSH mRNA expression levels coupled with the decreased ROS and MDA levels, compared to diabetic untreated rats. The gene discussed is GPX1; the disease is Hyperglycemia.