Relevant examples of these s kinds of investigations include the prevention of the metabolic syndrome development and the protection against heart failure by the bergamot extract [191,192] and the antioxidant effect of red orange extract in elderly subjects, which ameliorated their wellbeing (tested by SF-36 QoL and the MRS questionnaires) by reducing the TNF-α level and increasing GSH/GSSG ratio after an 8-week intake [193]. The gene discussed is TNF; the disease is metabolic syndrome.