Additionally, in mice, resveratrol appears to be able to prevent metabolic diseases (such as insulin resistance and obesity) by improving mitochondrial function through the activation of genes such as PGC-1α and SIRT-1 [42]; this result was later corroborated in another very similar study [43]. The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.