T cell CXCR3 and its ligands CXCL9 and CXCL10 as well as CCR5 and its ligands CCL3 and CCL5 are expressed at higher levels in disorders where Th1 immune responses predominate such as multiple sclerosis and rheumatoid arthritis [35]. Here, CXCL9 is linked to rheumatoid arthritis.