This study aimed to elucidate the epidemiological investigation and preliminary etiological analysis in the general development of ERIC-PCR to detect C. pseudotuberculosis genotype, characterize their susceptibility to antibacterial to select suitable antibacterial for treatment, and detect pathological changes and the immunohistochemical expression of NF-κB/p65, IL1β, and TNF within CLA granulomas. This evidence concerns the gene TNF and Granuloma.