Additional studies suggested that tissue eosinophils could promote neoangiogenesis and tumor development through the releasing of proangiogenic factors, such as VEGF, remodeling factors, such as fibroblast growth factor (b-FGF), GM-CSF, TGF-b, and MMP-9, but also IL-6, IL-8, and platelet-derived growth factor (PDGF) [6,69,70,71,72]. The gene discussed is CSF2; the disease is neoplasm.