ABCB6 and cancer: According to the KEGG analysis of the differential blood metabolites in both of the groups on day 72, the top 20 main enrichment pathways in the serum included the nine most significant metabolic pathways: valine, leucine, and isoleucine biosynthesis; protein digestion and absorption; mineral absorption; central carbon metabolism of cancer; amino acid biosynthesis; arginine and proline metabolism; aminoacyl tRNA biosynthesis; alanine, aspartate, and glutamate metabolism; and ATP-binding cassette (ABC) transport (Figure 6).