CHIT1 and obesity due to melanocortin 4 receptor deficiency: Thus, our study aimed to evaluate whether human circulating chitotriosidase activity, as an indicator of macrophage activation, is associated with changes in abdominal fat deposition (waist circumference, waist-to-hip ratio, and waist-to-height ratio) and IR (HOMA-IR and TG/HDLc) in children with obesity.