HSF4 and cataract: Affected individual 4 (Figure 2A) showed a novel heterozygous variant NM_001040667 c.341T>A: p. Leu114Gln in exon 5 of HSF4 (Figure 3 and Figure 4A), and cosegregation with cataracts was confirmed by Sanger sequencing of affected individuals 3 and 4 and the unaffected mother (Figure 1).