The independent factors associated with early antibiotic therapy were leukocytosis (adjusted odds ratio (aOR), 3.95; 95% confidence interval (CI), 1.76–9.27), C-reactive protein ≥50 mg/L (aOR, 4.19; 95% CI, 1.84–10.21), and performing abdominal imaging studies (aOR, 3.44; 95% CI, 1.55–7.99). Here, CRP is linked to Increased total leukocyte count.