In contrast, combined inhibition of HER2 and EDI3 in lapatinib-resistant HCC1954 cells was not significantly different from silencing EDI3 alone under most conditions tested (Fig. 4F and Supplementary Fig. S3E), suggesting that EDI3 may be an alternative target for HER2-targeted therapy resistant tumours. Here, GPCPD1 is linked to neoplasm.