Considering both the staining intensity and the fraction of EDI3-positive tumour cells, high protein expression was observed in 6% of ER + HER2-, 2% of ER − HER2-, 6% of ER + HER2 + , and 27% of ER − HER2 + tumours (Fig. 1B). The gene discussed is GPCPD1; the disease is neoplasm.