MT-RNR2 and age-related macular degeneration: Interestingly, treatment of age-related macular degeneration (AMD) with SHLP2 restored normal levels of OXPHOS complex protein subunits, increased the mitochondrial DNA copy number, attenuated amyloid beta-induced cellular and mitochondrial toxicity, inducesd anti-apoptotic effects, and prevented the loss of viable cells and mitochondria [29].