Our results, therefore, suggest that the effect of HDM varies in presence of different driver mutations, and further studies are needed to test the effects of HDM in other oncogene-driven LC models (e.g., epidermal growth factor receptor (EGFR)-mutant LC model as EGFR is one of the most frequently mutated driver gene in LC, particularly in non-smokers [84, 85]). This evidence concerns the gene EGFR and laryngotracheoesophageal cleft.