Asthma’s relationship to LC is still controversial, however, the recent discovery of different asthma endotypes Th2/Th17-low and Th2/Th17-predominant, in which IL-1β plays a critical role [88], may explain this controversy and help the design of future epidemiological studies that will take into account the heterogeneity of asthma. The gene discussed is IL1B; the disease is asthma.