NR3C2 and heart failure: In addition, MR activation promotes hypertension, fibrosis, and inflammation [45, 46], while pharmacological blockade of the MR has protective effects in animal models of CVDs [47, 48] and preventive effects against mortality and morbidity in heart failure patients [49, 50]. Thus, a better understanding of the implications of the MR in the setting of CVDs is critical for refining treatments and improving patient care.