CCN3 and congenital bilateral aplasia of vas deferens from CFTR mutation: Concordantly, the maximum valve thickness is also significantly larger in the Mye-CCN3-KO group when compared to the control group (Fig. 2C), strongly supporting that calcification on the aortic valve leaflet is causal for the observed increased CAVD-like symptoms in the myeloid-CCN3-deficient state.