Cardiac cachexia is a dangerous condition caused by heart failure (HF) that can be defined as “unexplained rapid weight loss of more than 5% (or BMI < 20 kg/m2) within 12 months with concomitant conditions such as decreased muscle strength, fatigue, anorexia, low fat-free mass index and abnormal blood biomarkers (elevated C-reactive protein and/or elevated interleukin-6 (IL-6), Hb < 12 g/dL, or low serum albumin (< 3.2 g/dL))”; at least three of the above must exist at the same time [1]. The gene discussed is IL6; the disease is heart failure.