MAPT and early-onset autosomal dominant Alzheimer disease: However, time did not seem to influence the CSF levels of the Alzheimer’s disease biomarkers (Aβ40: P = 0.79, Fig. 4C; Aβ42: P = 0.99, Fig. 4D; T-tau: P = 0.40, Fig. 4E; P-tau: P = 0.33, Fig. 4F).