In 3389 individuals with and without NAFLD, a positive connection between circulating RBP4 levels and NAFLD development was observed after 3.09 years of follow-up [Odds ratio (95% CI) for the development of NAFLD (three-digit: 2.01, (1.33, 3.04)] [35]. This evidence concerns the gene RBP4 and metabolic dysfunction-associated steatotic liver disease.