ATG4B and neoplasm: Interestingly, using in vitro functional assays and syngeneic animal models, Yamamoto and co-workers studied pancreatic ductal adenocarcinoma (PDAC) expressing a dominant-negative mutant of ATG4B and found that, PDAC tumors with autophagy ablation exhibited increased cytotoxic T cell infiltration in the tumor bed and subsequently restricted tumor growth [49••].