Type I IFNs and IFNγ are key regulators of immunity and inflammation, which induce overlapping ‘interferon signatures’ of canonical ISGs that encode molecules important for antigen presentation, inflammation, antiviral responses and autoimmunity.62 As the prototypic macrophage-activating factor, IFNγ is expressed by natural killer (NK) cells, Th1 cells, CD8+ cytotoxic T cells (CTLs) and innate lymphoid cells (ILCs) in response to stimulation from antigen receptors and inflammatory cytokines. Here, CD8A is linked to Autoimmunity.