MUC16 and metastatic neoplasm: Serum levels of MUC16/CA125 have been shown to be the strongest predictor of metastatic disease (AUC of 0.892 at 95% CI 0.846–0.938, p < 0.001) and survival (HR: 1.804, 95% CI 1.22–2.66, p = 0.003) compared to other markers (including CEA) in 180 PDAC patients55.