The qRT-PCR results demonstrated that four cellular senescence-related genes (CENPA, CXCL8, EZH2, and G6PD) and two chemokine-related genes (CCL26 and CXCL5) were overexpressed in tumor tissues from HCC patients compared with paraneoplastic tissues (Fig. 9). This evidence concerns the gene EZH2 and neoplasm.