MVMR results were ranked based on the number of times a lipid subfraction appeared to affect an outcome (based on the in the “Methods” described prioritization strategy), which is reflected in Fig. 3 as the number of ingoing arcs: CHD, CRP, SBP, carotid plaque, cIMT, HF, AD, T2DM, HbA1c, IBD, lung cancer, rectal cancer, estimated glomerular filtration rate (eGFR), and DBP. The 8 most frequently associated outcomes were presented in Figs. 4 and 5, with all of the MVMR results provided as Supplementary Data 1–12. The gene discussed is CRP; the disease is lung cancer.