This analysis confirmed independent CHD associations for HDL-C (OR per SD 0.80, 95%CI 0.74; 0.86) and Apo-B (OR per SD 1.81, 95%CI 1.64; 1.99), where the comparability between the univariable HDL-C association with CHD (OR per SD 0.75, 95%CI 0.70; 0.80) and the HDL-C estimate conditional on Apo-B and TG implies a lack of mediation by these co-variables. This evidence concerns the gene APOB and coronary artery disorder.