We found evidence that CHD and related traits, such as cIMT, carotid plaque, CRP, blood pressure, and HF, are causally affected by many lipid fractions typically including LDL-C, HDL-C, VLDL-C, IDL-C, TG, and apolipoproteins B and A1. The gene discussed is APOB; the disease is coronary artery disorder.