APOA1 and coronary artery disorder: Rather, the lack of association between HDL-C and CHD observed by Richardson et al. after adjustment for Apo-B, is more likely a result of forcing two nearly collinear variables (Apo-A1 and HDL-C) into the same multivariable model—a concern acknowledged by Richardson et al. To illustrate this we conducted a MVMR analysis jointly conditioning HDL-C on Apo-B, replacing the Apo-A1 variable by TG (Supplementary Data 12).