Our analyses additionally identified certain non-CVD traits that are more exclusively affected by smaller subset of exposures, such as Alzheimer’s disease (HDL-C, LDL-C, IDL-C, Apo-B), IBD (LDL-C, IDL-C), and T2DM (VLDL-C, IDL-C and LDL-C). Here, APOB is linked to early-onset autosomal dominant Alzheimer disease.