No brain atrophy was evident until animals reached at least until 3 months of age for GCLCfloxed X Iba1-Cre (Fig. S6 and Fig. S7A,D) mice and 8 months of age for GCLCfloxed X GFAP-Cre mice (Fig. S7A–C). This evidence concerns the gene AIF1 and Atrophy.