Interestingly, neither GRN (P = 0.42; odds ratio = 1.92; 95%CI, 0.31–11.6) nor TET2 (P = 0.31; odds ratio = 1.37; 95%CI, 0.71–2.62) showed suggestive rare variant burden in the replication dataset, consistent with their association to FTD and not ALS. Here, GRN is linked to amyotrophic lateral sclerosis.