In addition, we observed reduced expression of NUP50 in hiPSC-derived motoneurons of patients with ALS mutations, including FUS (n = 2), TARDBP (n = 2), and C9ORF72 (n = 2) (Fig. S3a, b) as well as in motor neurons of mice expressing either ALS linked mutant SOD1 or mutant FUS (Fig. S3c, d), consistent with previously published results20, 38. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.