JAKMIP3 and amyotrophic lateral sclerosis: Moreover, meta-analysis using a Stouffer’s weighted z-score method of both discovery and replication TWAS yielded 3 novel associations such as SLC9A8 (Z-meta = 5.31, p = 1.06 × 10−7), which is a known ALS locus, JAKMIP3 (Z-meta = 4.82, p = 1.36 × 10−6) and NDUFC2 (Z-meta = −5.03, p = 4.88 × 10−7) (Fig. 2).