TARDBP and amyotrophic lateral sclerosis: In addition, we observed reduced expression of NUP50 in hiPSC-derived motoneurons of patients with ALS mutations, including FUS (n = 2), TARDBP (n = 2), and C9ORF72 (n = 2) (Fig. S3a, b) as well as in motor neurons of mice expressing either ALS linked mutant SOD1 or mutant FUS (Fig. S3c, d), consistent with previously published results20, 38.