In our discovery TWAS, we integrated genetic data from 12,577 cases and 23,475 controls7 to our 13 reference panels which yielded 3 genome wide significant association among them 2 known ALS loci, C9ORF72 (Z = 8.81, p = 1.91 × 10−18) and SCFD1 (Z = 5.15, p = 2.5 × 10−7) and a novel candidate gene NUP50 (Z = −4.6, p = 1.94 × 10−6) (Fig. 2, Table 1, Source Data). Here, NUP50 is linked to amyotrophic lateral sclerosis.