Supporting this, the ALS risk allele (rs6006950-G) at the NUP50 locus was associated with decreased expression of NUP50 in the DLPFC (rs6006950, p = 7.5 × 10−13), but not in the blood (p = 0.061) (Fig. 4a, b). This evidence concerns the gene NUP50 and amyotrophic lateral sclerosis.