Further supporting a role for NUP50 in ALS, we observed downregulation of NUP50 mRNA in the cortex of ALS patients (Fig. 4g, Source Data), and a trend towards decreased mRNA levels in FUS-FTD, but not TAU or TDP-43 FTD (Fig. 4g, Source Data). Here, TARDBP is linked to amyotrophic lateral sclerosis.