In this replication cohort, GWAS revealed three genome-wide significant associations in C9ORF72 (rs700828, p-value = 7.2 × 10−9), GPX3/TNIP1 (rs8177447, p-value = 2.74 × 10−9) and UNC13A (rs12608932, p-value = 2.94 × 10−8), which are known ALS loci. The gene discussed is TNIP1; the disease is amyotrophic lateral sclerosis.