Strikingly, among these 6 RBPs, we observed target sites of TDP-43 (τ* = 0.72; p-jackknife = 2.9 × 10−3) and FUS (τ* = 0.36, p-jacknife = 2.6 × 10−3), that contributed significantly to ALS heritability, but also associations with novel RBPs such as KHSRP (τ* = 0.52, p-jacknife = 4.2 × 10−3) or AQR (τ * = 1.44, p-jacknife = 9.9 × 10−4). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.