In contrast, while proof of principle homing drives have been demonstrated in the dengue and yellow fever mosquito Aedes aegypti, the conversion rates achieved so far have been more modest (highest reported average drive inheritance rate = 80.5% in wU6b-GDe;nup50-Cas9 trans-heterozygous females, with wU6b-GDe;nup50-Cas9 trans-heterozygous males showing a lower rate of 66.9%)10. This evidence concerns the gene NUP50 and dengue disease.