To determine if other genomic factors could be involved in generating AS in MM we performed 18 comparisons that cover all major cytogenetic subgroups (IgH translocations and hyperdiploidy) and the most common mutations found in MM (BRAF, KRAS, NRAS, DIS3, TENT5C, and TP53), SF3B1 mutation and SF3B1 mutation hotspots, as well as those with biallelic abnormalities including DIS3, TENT5C, and TP53, chromosome 1q gain and amplification, plus one combination event where there is an association of DIS3 mutations in the t(4;14) (t(4;14) + DIS3 mutation). The gene discussed is SF3B1; the disease is Miyoshi myopathy.