Inhibition of EZH2 significantly elevated FOXP2 mRNA expression in human cancer lines H460, H2030, A549, and H2009, and immortalized pulmonary epithelial cells BEAS2B and BEAS2B with additional KRASG12V and TP53R175H mutations (BEAS-KP) (Fig. 4g). This evidence concerns the gene FOXP2 and cancer.