ALDH2 and acute kidney injury: Although ALDH2 protects against oxidative stress-induced organ damage by detoxifying endogenous aldehydes such as 4-HNE and malondialdehyde (MDA) produced by lipid peroxidation [34], this is the first study to show that ALDH2 maintains mitochondrial homoeostasis and energy metabolism, highlighting a novel regulatory mechanism in AKI.