In ALDH2 KO mice with Cis-AKI, the Scr (86.13 ± 6.20 versus 62.29 ± 3.19 μmol/L, P < 0.01), BUN (39.78 ± 1.42 versus 27.13 ± 2.25 μmol/L, P < 0.001), and tubular injury were more severe than wild-type (WT) Cis-AKI mice (Fig. 2A, B). This evidence concerns the gene ALDH2 and acute kidney injury.