ALDH2 and acute kidney injury: ALDH2 agonist Alda-1 prevented the increase of Scr (38.54 ± 4.92 versus 74.42 ± 4.39 μmol/L, P < 0.0001) and BUN (20.56 ± 0.34 versus 31.88 ± 1.68 μmol/L, P < 0.001) compared to Cis-AKI mice, and alleviated the renal proximal tubular histopathological injury, with partially increased ALDH2 levels (Fig. 1A–D).